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. 2021 May 7;11(5):1238. doi: 10.3390/nano11051238

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Nitric oxide synthase activities in (a) aorta, (b) left heart ventricle, (c) liver, (d) hypothalamus, and (e) kidney after IV administration of Fe₃O₄@PEG-Ale nanoparticles in rats. The values represent the mean ± SEM. * p < 0.05 vs. control group, n = 6–7 per group. Cont, control; NOS, nitric oxide synthase; Fe₃O₄@PEG-Ale, Fe₃O₄@PEG-alendronate nanoparticles.