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Maximal depolarization-induced contractions produced by (a) KPSS and (b) serotonin (5-hydroxytryptamine)-induced contractions in the absence and presence of NO synthase inhibitor L-NAME. The values represent mean ± SEM. * p < 0.05 vs. 5-HT, n = 12 per group. Cont, control; Fe3O4@PEG-Ale, Fe3O4@PEG-alendronate nanoparticles; KPSS, high concentration of potassium (125 mmol/L)-containing physiological saline solution; 5-HT, serotonin; L-NAME, N(ω)-nitro-L-arginine methyl ester.
