Table 2.

The predicted (Pre) and observed (Obs) pharmacokinetic parameters of metformin and perpetrators.

Drug	Ref.	Dose (mg)	Cmax (μg/mL)		Ratio	AUC0–t (μg·h/mL)		Ratio
			Pre	Obs	Pre/Obs	Pre	Obs	Pre/Obs
Metformin	[68]	750	1.22	1.5	0.81	11.05	9.4	1.18
	[69]	500	0.95	1.55	0.61	7.04	9.08	0.78
Cimetidine	[70]	400	2.06	2.20	0.94	9.17	8.03	1.14
	[71]	300	1.53	1.53	1.00	6.68	5.22	1.28
Pyrimethamine	[72]	50	0.57	0.76	0.75	31.18	76	0.41
	[73]	50	0.57	0.37	1.54	31.18	42.83	0.73
	[74]	75	0.86	0.86	1.00	46.77	124.6	0.38
	[75]	75	0.86	0.60	1.43	46.77	68.34	0.68
Trimethoprim	[76]	210	2.18	2.35	0.93	28.26	37.1	0.76
	[77]	1400	13.76	12.78	1.08	302.34	299.31	1.01
Ondansetron	[78]	8	0.046	0.0272	1.69	0.203	0.198	1.03
	[79]	8	0.046	0.037	1.24	0.233	0.254	0.92
Rabeprazole	[80]	40	0.40	0.502	0.80	1.27	1.315	0.97
	[80]	40	0.40	0.444	0.90	1.27	1.332	0.95
	[81]	20	0.20	0.252	0.79	0.63	0.575	1.10
Verapamil	[82]	40	0.050	0.033	1.52	0.28	0.22	1.27
	[83]	80	0.099	0.13	0.76	0.564	0.387	1.46