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. 2021 May 8;14(5):443. doi: 10.3390/ph14050443

Figure 2.

Figure 2

Schematic representation of the CRLF2-JAK-STAT signaling pathway. In addition to the common gamma chain, interleukin-7 receptor alpha (IL-7Rα) can form heterodimers with cytokine receptor-like factor 2 (CRLF2), thereby creating the receptor for thymic stromal lymphopoietin (TSLP). Whereas IL-7-induced signaling activates signal transducer and activator of transcription 5 (STAT5) via the phosphorylation of Janus kinase 1 (JAK1) and JAK3, the binding of TSLP to the TSLP receptor results in STAT5 activation via the phosphorylation of JAK1 and JAK2.