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. 2021 May 8;10(5):417. doi: 10.3390/biology10050417

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Biological pathways of miR-21 in gastrointestinal cancers. MiR-21 is commonly found to be overexpressed in human cancer, which causes the downregulation of its target genes, including phosphatase and tensin homolog (PTEN), Programmed Cell Death 4 (PDCD4), reversion-inducing-cysteine-rich protein with kazal motifs (RECK), sprouty RTK signaling antagonist 2 (SPRY2), and von Hippel-Lindau (VHL), thereby promoting survival, proliferation, migration, and metastasis of cancer cells. This figure was made using www.biorender.com.