Table 2.
Polyunsaturated fatty acids (PUFA) content in the FFA fraction (nmol/g of wet tissue) in the red gastrocnemius muscle in the control (standard diet) and high-fat diet (HFD) groups after two-week cannabidiol (CBD) treatment.
| Fatty Acid | Control | CBD | HFD | HFD + CBD |
|---|---|---|---|---|
| (18:2n6c) | 356.30 ± 78.40 | 495.83 ± 44.51 * | 626.91 ± 53.59 * | 582.61 ± 59.54 * |
| (20:4n6) | 77.08 ± 9.82 | 109.19 ± 5.69 * | 109.23 ± 5.12 * | 153.63 ± 7.87 *,# |
| (18:3n3) | 26.26 ± 5.10 | 35.10 ± 3.11 * | 33.54 ± 4.00 * | 31.08 ± 3.65 * |
| (20:5n3) | 3.56 ± 0.82 | 4.71 ± 0.52 * | 3.59 ± 0.62 | 4.12 ± 0.66 *,# |
| (22:6n3) | 35.16 ± 8.30 | 46.17 ± 7.06 * | 61.57 ± 8.15 * | 71.30 ± 8.90 *,# |
| n-6 PUFAs | 433.38 ± 87.32 | 606.71 ± 48.96 * | 736.14 ± 57.79 * | 739.06 ± 64.82 * |
| n-3 PUFAs | 64.85 ± 13.92 | 85.98 ± 8.19 * | 99.32 ± 11.71 * | 109.76 ± 6.85 * |
The data are expressed as mean values ± SD, n = 10 in each group. * p < 0.05 indicates a significant difference: the control group vs. the examined group in the red gastrocnemius muscle; # p < 0.05 indicates a significant difference: HFD vs. HFD + CBD in the red gastrocnemius muscle; 18:2n6c (linoleic acid, LA); 20:4n6 (arachidonic acid, AA); 18:3n3 (α-linolenic acid, ALA); 20:5n3 (eicosapentaenoic acid, EPA); 22:6n3 (docosahexaenoic acid, DHA).