Table 4.
Polyunsaturated fatty acids (PUFA) content in the DAG fraction (nmol/g of wet tissue) in the red gastrocnemius muscle in the control (standard diet) and high-fat diet (HFD) groups after two-week cannabidiol (CBD) treatment.
| Fatty Acid | Control | CBD | HFD | HFD+CBD |
|---|---|---|---|---|
| (18:2n6c) | 79.55 ± 22.95 | 74.12 ± 5.14 | 145.53 ± 26.29 * | 135.21 ± 18.06 * |
| (20:4n6) | 34.20 ± 5.68 | 44.42 ± 4.89 * | 40.54 ± 2.42 * | 61.16 ± 5.46 *,# |
| (18:3n3) | 5.83 ± 1.61 | 5.82 ± 0.43 | 7.66 ± 0.51 * | 8.45 ± 1.03 *,# |
| (20:5n3) | 0.97 ± 0.18 | 1.36 ± 0.27 * | 1.20 ± 0.61 | 1.75 ± 0.50 *,# |
| (22:6n3) | 9.09 ± 2.84 | 9.91 ± 2.02 | 17.60 ± 2.67 * | 21.02 ± 2.85 *,# |
| n-6 PUFAs | 118.71 ± 32.16 | 118.54 ± 9.37 | 186.07 ± 26.82 * | 202.15 ± 20.80 * |
| n-3 PUFAs | 15.91 ± 4.80 | 16.81 ± 2.33 | 26.59 ± 2.56 * | 31.22 ± 3.82 *,# |
The data are expressed as mean values ± SD, n = 10 in each group. * p < 0.05 indicates a significant difference: the control group vs. the examined group in the red gastrocnemius muscle; # p < 0.05 indicates a significant difference: HFD vs. HFD + CBD in the red gastrocnemius muscle; 18:2n6c (linoleic acid, LA); 20:4n6 (arachidonic acid, AA); 18:3n3 (α-linolenic acid, ALA); 20:5n3 (eicosapentaenoic acid, EPA); 22:6n3 (docosahexaenoic acid, DHA).