Table 6.
Polyunsaturated fatty acids (PUFA) content in the TAG fraction (nmol/g of wet tissue) in the red gastrocnemius muscle in the control (standard diet) and high-fat diet (HFD) groups after two-week cannabidiol (CBD) treatment.
| Fatty Acid | Control | CBD | HFD | HFD + CBD |
|---|---|---|---|---|
| (18:2n6c) | 775.65 ± 666.51 | 689.35 ± 226.72 | 1682.96 ± 820.25 * | 1113.21 ± 353.52 # |
| (20:4n6) | 38.74 ± 26.02 | 36.78 ± 9.81 | 39.97 ± 17.23 | 39.70 ± 7.85 |
| (18:3n3) | 69.66 ± 55.34 | 66.62 ± 22.17 | 88.41 ± 37.28 | 79.79 ± 19.00 |
| (20:5n3) | 4.35 ± 1.60 | 4.15 ± 1.42 | 3.34 ± 1.02 | 4.91 ± 1.68 # |
| (22:6n3) | 12.72 ± 5.21 | 13.39 ± 3.49 | 33.26 ± 6.73 * | 44.49 ± 4.76 *,# |
| n-6 PUFAs | 965.12 ± 806.91 | 726.13 ± 236.31 | 1724.88 ± 837.21 * | 1086.75 ± 311.93 # |
| n-3 PUFAs | 75.11 ± 49.38 | 83.67 ± 21.26 | 136.52 ± 53.96 | 129.19 ± 19.33 |
The data are expressed as mean values ± SD, n = 10 in each group. * p < 0.05 indicates a significant difference: the control group vs. the examined group in the red gastrocnemius muscle; # p < 0.05 indicates a significant difference: HFD vs. HFD + CBD in the red gastrocnemius muscle; 18:2n6c (linoleic acid, LA); 20:4n6 (arachidonic acid, AA); 18:3n3 (α-linolenic acid, ALA); 20:5n3 (eicosapentaenoic acid, EPA); 22:6n3 (docosahexaenoic acid, DHA).