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. 2021 May 12;9(5):542. doi: 10.3390/biomedicines9050542

Figure 1.

Figure 1

Early systemic G-CSF treatment alleviated mechanical allodynia in rats with chronic constriction injury (CCI) from the 1st to the 7th days after nerve injury. Significant mechanical allodynia developed in vehicle-treated CCI rats compared to sham control rats from the 1st to the 7th day after nerve injury (## p < 0.01: vehicle-treated CCI rats compared to sham-operated control rats). In contrast, early G-CSF treatment alleviated mechanical allodynia from the 1st to the 7th day after nerve injury compared to that in vehicle-treated CCI rats (** p < 0.01: G-CSF-treated CCI rats compared to vehicle-treated CCI rats). The data are shown as the mean ± SEM. n = 9 in each group.