Table 2.
Effect of F16-betulin on oxygen consumption by rat liver mitochondria fueled by succinate.
| Additions | State 2 | State 3 | State 4 | State 3UDNP | RC |
|---|---|---|---|---|---|
| nmol O2/min/mg Protein | Relative Units | ||||
| Control | 9.86 ± 0.91 | 44.62 ± 2.30 | 9.14 ± 0.67 | 49.54 ± 2.96 | 4.91 ± 0.15 |
| F16-betulin conjugate | |||||
| 10 μM | 9.56 ± 1.00 | 44.91 ± 0.55 | 9.39 ± 1.27 | 51.16 ± 0.94 | 4.87 ± 0.44 |
| 20 μM | 9.85 ± 0.11 | 40.67 ± 0.83 | 9.25 ± 0.43 | 43.25 ± 0.51 | 4.41 ± 0.12 |
Oxygen consumption by mitochondria was driven by succinate in the presence of rotenone. Table shows means ± SEM (n = 3).