Table 1.

List of host proteins to which NSs interacts.

Protein	Effect of Interaction
TBK1	Suppressed IFN responses and activated NF-κB signaling [14,32]
LC3-II	Promoted viral replication and autophagy regulation during SFTSV infection [23]
TRIM25	Inhibited ubiquitination and activation of RIG-I [11]
IRF3	Inhibited transcription of IFN-I [14]
IRF7	Inhibited transcription of IFN-I [12]
STAT2	Suppressed JAK/STAT signaling and abrogated ISG production [16,17]
IKKε	Suppressed IFN responses [14]
CDK1	Cell cycle arrest at G2/M transition [28]
ABIN2	Activated TPL2 signaling and IL-10 production [33]
p62	Unknown role in autophagy regulation [24]
Lamp2b	Unknown role in autophagy regulation [23]