Table 3.
Agreement for PK/PD target attainment based on measured and predicted unbound concentration of ceftriaxone.
| 100% fT>MIC, n (%) |
p-Value a | 100% fT>4xMIC, n (%) |
p-Value a | |
|---|---|---|---|---|
| Fixed average protein binding | 26 (81.2) | 1.000 | 11 (34.4) | 0.044 |
| Predicted saturable concentration-dependent protein binding, Equation (4) | 23 (71.2) | 0.083 | 5 (15.6) | 0.0007 |
| Predicted protein binding, present study, Equation (2) | 24 (75) | 0.572 | 13 (40.6) | 1.000 |
| Predicted protein binding, Bos | 25 (78.1) | 0.325 | 13 (40.6) | 0.325 |
| Predicted protein binding, Leegwater | 25 (78.1) | 0.325 | 11 (34.4) | 0.044 |
100% fT>MIC: free concentration above the minimum inhibitory concentration over the whole dosing interval (100%); 100% fT4x>MIC: free concentration above 4 times the minimum inhibitory concentration over the whole dosing interval (100%). a Null hypothesis = no difference (i.e., agreement) in PK/PD target attainment based on measured vs. predicted CEFu.