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. 2021 May 10;11(5):426. doi: 10.3390/life11050426

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Monthly mean (±SD) of TSH, T4, T3, GH values in prepubertal subjects. (B) Single cosinor display of circannual variations in these hormone concentrations and their characteristics, visualized by polar cosinor plot. A significant rhythm was validated only for TSH, as revealed by its ellipse (continuous tract), which does not cover the pole (zero: center), and with acrophase in December, as indicated by the arrow starting from the center and directed towards December (confidence limits October–February) [68].