Table 2.
Transgenic murine models targeting respiratory epithelial cell subtypes.
| Target Cell | Murine Line | Mutation | Models Investigated Using Line |
|---|---|---|---|
| Respiratory epithelium | IKK∆LEC | Lack NFκB signaling in lung epithelium | B. dermatitidis, H. capsulatum, C. neoformans |
| Club cells | DNTA | Lack NFκB signaling in club cells | B. dermatitidis, H. capsulatum |
| Muc5bLung KO | Conditional Muc5b KO using SCGB1A promoter | Characterized | |
| Goblet cells | Muc5ac-Tg | Overexpression of Muc5ac mRNA | Influenza |
| PNECs | Ascl1CKO | Deficient in Ascl1 in PNEC progenitors | OVA asthma model |
| Ionocyte | Foxi1KO | Deficient in Foxi1 | CF |