Table 3.
miRNA experimentally observed as involved in osteoarthritis and modulated by IL-1β treatment.
| miRNA | Target Genes | miRNA Properties | |
|---|---|---|---|
| Up-regulated | miR-146a-5p | SMAD4, VEGF, Bcl2 | TGFβ signaling inhibition, modulate chondrocytes apoptosis/autophagy and inflammatory functions |
| miR-155-5p | CEBPB, CTNNB1, SMAD1, TCF7L2 | Chondroprotective (suppress MMP-1 and MMP-3 production), Wnt signaling inhibition, modulate inflammatory functions | |
| miR-520c-3p | DKK1, RELA, SEMA3C | Wnt signaling activation, modulate inflammatory functions and chondrogenesis | |
| Activated | miR-127-5p | MMP13 | Chondroprotective (suppress MMP-13 production) |
| miR-326 | SMO | Chondroprotective | |
| miR-377-3p | CART1 | Cartilage homeostasis | |
| miR-449b-5p | JAG1, NOTCH1, SIRT1 | Chondroprotective (NOTHC signaling inhibition), senescence dysregulation | |
| miR-483-3p | ACAN | Cartilage homeostasis | |
| miR-519a-3p | PRKAA1 | Senescence and autophagy dysregulation | |
| miR-520b | DKK, RELA | Wnt signaling activation, modulate inflammatory functions | |
| Silenced | miR-135b-5p | RUNX2, SMAD5 | Wnt signaling inhibition, inhibition of osteogenic differentiation |
| miR-23b-3p | HES1, NOTCH1, PRKACB, CRTAP | Chondroprotective (NOTHC signaling inhibition), cartilage homeostasis | |
| miR-302d-3p | DKK1, RELA | Wnt signaling activation, modulate inflammatory functions | |
| miR-378a-3p | CASP9 | Marker of late stage OA |