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. 2021 May 12;13(5):701. doi: 10.3390/pharmaceutics13050701

Table 3.

Effect of different segments and chain extender on the properties of PU [56].

Segment Effect
PEG Increases solubility and hydrolytic degradation
PTCM Contributes to maintain mechanical properties for long periods
PCL Improves hydrolytic degradation
GAE Reduces enzymatic biodegradation rate
PCN Provides high tensile strength, yields relatively low pro-inflammatory degradation products
HEMA Confers cross-linking functionality to the polymer
DTH Contributes to peptide degradation by products
ISO Enhances biological activity

PTCM: polytrimethylene carbonate, GAE: glycerol α-monoallyl ether, PCN: polyhexamethylene carbonate diol, HEMA: hydroyethyl methacrylate, DTH: desamino tyrosine tyrosyl hexyl ester, ISO: 1,4:3,6-dianhydro-D-sorbitol.