Figure 4.

Molecular interactions of inhibitors with 5-lipoxygenase (5-LOX). (A) trans-cinnamic acid bound to an allosteric binding pocket (general view). The protein is shown in dark blue cartoon representation, trans-cinnamic acid in yellow ball representation and iron ion in magenta ball representation. (B) trans-cinnamic acid, (C) syringic acid and (D) ferulic acid in a binding pocket of 5-LOX. The protein is shown with cyan carbon atoms in wire representation with the most important residues shown as sticks. Inhibitors are depicted with gray carbon atoms in stick representation. Polar bonds are shown as red dashes. Nonpolar hydrogen atoms omitted for clarity.