Table 2.
Mode of inhibition, Ki (Km without inhibitor), Vmax and IC50 values of chosen phenolic acids on lipoxygenase (LOX) activity.
| Compound | Mode of Inhibition | Ki [mM] (Km without Inhibitor) |
Vmax [ΔAU/min] |
IC50 [mM] |
|---|---|---|---|---|
| Linoleic acid * | - | 0.007 ± 0.0003 a | 1111 ± 45.1 a | - |
| trans–cinnamic acid | uncompetitive | 0.009 ± 0.0004 c | 556 ± 10.13 b | 0.009 ± 0.0004 b |
| Syringic acid | uncompetitive | 0.005 ± 0.0003 d | 526.3 ± 11.02 c | 0.009 ± 0.0004 b |
| Ferulic acid | uncompetitive | 0.008 ± 0.0004 b | 455 ± 9.9 d | 0.027 ± 0.0013 a |
* LOX substrate values are expressed as the mean ± SD; means with different letter superscripts (a–d) in the columns are significantly different (α = 0.05).