Table 2.

Patient stratification according to their response to treatment (target variables). Response to treatment is defined into more detail in the supplementary file. Ppb: parts per billion.

Class	FEV1	MEF50	FENO	Asthma Control
Responders	Increase ≥ 10% predicted	Increase ≥ 15% predicted	Decrease < 20% for values > 35 (50) ppb or < 10 ppb for values < 35 (50) ppb	Improvement in asthma control
Non-Responders	Change < 10% predicted	Change < 15% predicted	Decrease ≤ 20% FENO ≤ 20% for values over 35 (50) ppb or ± 10 ppb for values < 35 (50) ppb or increase >20% for values > 35 (50) ppb or > 10 ppb for values < 35 (50) ppb	No changes in partial asthma control or deterioration in asthma control

FEV1—forced expiratory volume in one second, MEF50—maximal expiratory flow at 50% of the vital flow capacity, FENO—Fractional Exhaled nitric oxide.