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. 2021 May 10;14(5):449. doi: 10.3390/ph14050449

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 2 — Reagents and conditions: (a) Piperidine/DMF (1/4); (b) 7a, HOBt, DIC, 1-methyl-2-pyrrolidinone (NMP); (c) 7b, HOBt, DIC, NMP; (d) DMP, DCM; (e) PPh₃, I₂, DIPEA, DCM; (f) TFA/ Triisopropylsilane (TIPS)/DCM (1/5/94); (g) carboxylic acid, HOBt, DIC, NMP or acetic anhydride, DIPEA, NMP; (h) TFA/TIPS/H₂O (95/2.5/2.5).