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. 2021 May 10;14(5):449. doi: 10.3390/ph14050449

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme 3 — Reagents and conditions: (a) 14, DIC, DMF; (b) R¹NH₂ or R²NH₂, DMF; (c) 4,6-dichloro-2-(methylthio)pyrimidine-5-carbaldehyde, DIPEA, DMF; (d) DBU, DMF, MeOH, 90 °C; (e) 3-chloroperbenzoic acid (mCPBA), NaHCO₃, DCM; (f) R³NH₂, DIPEA, NMP, 170 °C; (g) TFA/TIPS/H₂O (95/2.5/2.5), 2 h.