Table 2:

Defining alcohol associated hepatitis, modified from NIAAA AH clinical trial definition (Crabb et al Gastroenterology 2016)

Definition	Clinical entity with rapid onset of jaundice with elevated AST in background of heavy alcohol use.
Pattern of alcohol use	Heavy alcohol use for >6 months, <60 days of abstinence before onset of jaundice.
Supporting features
Biopsy	steatohepatitis, cholestasis, severe fibrosis
Presentation	malaise, tender hepatomegaly, decompensation
Labs	Br>3, AST/ALT ratio 1.5, AST<400
Exclude	Drug induced liver injury, biliary obstruction, viral hepatitis, autoimmune liver disease, Wilson disease
Spectrum	AH versus acute on chronic liver failure Presence of cirrhosis
Definite	Clinical and biopsy proven
Probable	Clinical and exclude competing
Possible Biopsy recommended	Clinically diagnosed but with potential confounding factors (e.g. pt denies alcohol)
Associated other diagnoses?	E.g. Viral hepatitis