Table 2.
Biological activity of tambjamines, Obatoclax, synthetic and natural prodigiosins, and benznidazole against trypomastigotes/amastigotes of T. cruzi (CLB strain) at the highest concentration assayed (16 µM).
| Compound | % Trypomastigote/Amastigote Growth Inhibition (%T/A GI ± SD) * |
IC50 (µM) ƚ |
|---|---|---|
| MM3 | 97.09 ± 3.01 | 1.9 ± 0.45 |
| MM4 | ND | ND |
| Obatoclax | 88.42 ± 6 | 2.60 ± 0.4 |
| Synthetic prodigiosin | 100 ± 0 | 0.57 ± 0.19 |
| Natural prodigiosin | 100 ± 0 | 0.1 ± 0.04 |
| Benznidazole | 76.01 ± 5.02 | 1.76 ± 0.34 |
MM3 and MM4 are tambjamines; SD, standard deviation; ND, not determined. * The results are expressed as the mean value of trypomastigote/amastigote growth inhibition (% T/A GI) at the highest concentration assayed (16 µM) ± SD (n = 9) using data obtained in triplicate runs from three independent experiments. ƚ The concentration causing 50% trypomastigote/amastigote growth inhibition was calculated using the GraphPad Prism software.