Table 1.
Analogues of Dappu-RPCH together with their EC50 values tested on the Daphnia pulex RPCH receptor according to [13]. Mutated residues are shown in red.
| Peptide Name | Peptide Sequence | EC50 Value (M) | ||
|---|---|---|---|---|
| Dappu-RPCH | pQVNFSTSWamide | 6.45E-11 | ||
| [Ala2]Dappu-RPCH | pQANFSTSWamide | 1.77E-08 | ||
| [Ala3]Dappu-RPCH | pQVAFSTSWamide | 1.56E-07 | ||
| [Ala4]Dappu-RPCH | pQVNASTSWamide | 2.99E-07 | ||
| [Ala5]Dappu-RPCH | pQVNFATSWamide | 3.61E-09 | ||
| [Ala6]Dappu-RPCH | pQVNFSASWamide | 5.32E-10 | ||
| [Ala7]Dappu-RPCH | pQVNFSTAWamide | 3.55E-10 | ||
| [Ala8]Dappu-RPCH | pQVNFSTSAamide | 1.31E-07 | ||
| [Ace]Dappu-RPCH | [NAc-Ala]-VNFSTSWamide | 4.87E-08 | ||
| [COOH]Dappu-RPCH | pQVNFSTSW-OH | 1.74E-08 | ||
| Placa-HrTH | pQVNFSPSWGNamide | 6.64E-10 | ||
| [Pro6]Dappu-RPCH= Anaim-AKH | pQVNFSPSWamide | 2.24E-10 | ||
| [Gly7]Dappu-RPCH= Grybi-AKH | pQVNFSTGWamide | 6.67E-11 | ||
| [Lys7]Dappu-RPCH=Argsi-RPCH | pQVNFSTKWamide | 2.13E-8 | ||
| [Gly8]Dappu-RPCH | pQVNFSTSGamide | - | ||
| [Gly5]Dappu-RPCH | pQVNFGTSWamide | - | ||
| [Gly6]Dappu-RPCH | pQVNFSGSWamide | - | ||