Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 May 11;22(10):5083. doi: 10.3390/ijms22105083

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Measurement of visual function in Exoc5fl/fl;Best1-Cre⁺ mice by full-field electroretinography (ERG). Dark-adapted, scotopic ERGs were recorded in response to increasing light intensities in cohorts of 6, 20, and 27-week old control (Exoc5fl/fl) and Exoc5fl/fl;Best1-Cre⁺ mice. RPE-specific Exoc5 knockout mice in which both copies of Exoc5 were eliminated showed progressively significantly lower dark-adapted a- and b-wave amplitudes compared to controls (posthoc ANOVA: a-waves p < 0.03; b-waves p < 0.01), in particular at higher light intensities (20, 10, 6, 0 dB). C-waves showed an age-dependent decline in amplitude in the Exoc5 fl/fl;Best1-Cre⁺ mice (p = 0.002). Data are expressed as mean ± SEM (Exoc5 fl/fl;Best1-Cre^-: n = 10; and Exoc5 fl/fl;Best1-Cre⁺ mice: n = 10).