Table 1.

Growth-inhibitory effects as IC₂₀, IC₅₀, and IC₈₀ (µg·mL⁻¹) values of compounds 2, 4, 6, 8c, 9c, 10a-c, and DCF on the three cancer cell lines B16-F10, Hep-G2, and HT29. The last column represents the ratio between IC₅₀ values of DCF and the corresponding N-derivative.

Cell Line	Compound #	IC20	IC50	IC80	IC50 of DCF/ IC50 of Compound
B16-F10	DCF	34.58 ± 8.46	52.45 ± 3.58	83.75 ± 0.54	1.0
	2	21.94 ± 3.44	40.77 ± 1.33	56.59 ± 1.29	1.3
	4	37.15 ± 0.07	37.79 ± 0.17	N/A	1.4
	6	28.22 ± 2.82	45.77 ± 6.46	N/A	1.1
	8c	14.83 ± 3.24	25.55 ± 1.19	42.01 ± 1.59	2.1
	9c	21.19 ± 2.00	27.35 ± 0.14	33.59 ± 1.06	1.9
	10a	26.79 ± 5.11	N/A	N/A	N/A
	10b	6.93 ± 5.48	35.45 ± 4.30	80.98 ± 0.33	1.5
	10c	27.42 ± 6.76	48.20 ± 3.05	63.56 ± 1.19	1.1
Hep-G2	DCF	32.48 ± 2.51	46.87 ± 0.97	76.87 ± 1.60	1.0
	2	18.45 ± 0.56	24.53 ± 1.11	35.28 ± 3.91	1.9
	4	7.53 ± 3.02	14.56 ± 3.07	33.06 ± 2.07	3.2
	6	12.30 ± 1.00	21.58 ± 1.77	52.70 ± 7.38	2.2
	8c	12.83 ± 1.12	18.48 ± 1.25	29.74 ± 3.03	2.5
	9c	17.62 ± 1.42	28.60 ± 1.75	49.21 ± 4.22	1.6
	10a	23.15 ± 8.17	78.93 ± 10.67	146.47 ± 13.76	0.6
	10b	40.63 ± 9.57	111.26 ± 16.58	184.08 ± 27.89	0.4
	10c	17.41 ± 1.08	21.89 ± 0.90	32.33 ± 3.34	2.1
HT29	DCF	45.27 ± 0.52	52.63 ± 0.54	65.90 ± 2.12	1.0
	2	18.56 ± 1.26	28.66 ± 1.91	49.14 ± 6.00	1.8
	4	3.90 ± 4.74	19.80 ± 9.02	173.90 ± 25.19	2.7
	6	7.70 ± 4.60	13.23 ± 4.24	30.53 ± 11.87	4.0
	8c	14.10 ± 1.37	20.65 ± 0.76	30.48 ± 0.66	2.5
	9c	17.94 ± 1.06	24.93 ± 1.21	41.02 ± 3.24	2.1
	10a	62.79 ± 15.01	95.77 ± 7.88	113.61 ± 5.75	0.5
	10b	48.12 ± 2.33	69.52 ± 2.86	96.54 ± 1.50	0.8
	10c	31.10 ± 3.38	69.30 ± 2.36	103.99 ± 0.79	0.8