Table 2.
Examples of Tubulysin-derived payloads linked through a modified phenyl group.
| ||||
|---|---|---|---|---|
| R1 | R2 | R3 | R4 | |
| AstraZeneca |
|
Et | Ac | (CH2)4NH2 |
| Bristol-Myers Squibb |
|
nPr | Me | (CH2)4NH2CONH2 |
| Pfizer |
|
Me | CONHEt | H |
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