Table 1.
Site of synthesis and main source of major pro- and anti-fibrinolytic proteins discussed within this review.
| Protein | Origin | Major Source |
|---|---|---|
| Factor XIII | Cellular (megakaryocytes, platelets, monocytes, osteoblasts) Plasma |
Platelets |
| Factor V | Liver, platelets and plasma | Liver |
| Factor X | Liver and plasma | Liver |
| Factor VIII | Liver, endothelial cells and plasma | Liver |
| Prothrombin | Liver and plasma | Liver |
| Plasminogen activator inhibitor (PAI) | Endothelial cells, liver, adipose tissue, plasma and platelets | Platelets |
| Tissue plasminogen activator (t-PA) | Endothelial cells, mesothelial cells, megakaryocytes and plasma | Endothelial cells |
| Fibrinogen | Liver, plasma (predominantly), platelets, lymph and interstitial fluid | Liver |
| ⍺2-antiplasmin | Liver and plasma | Liver |