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. 2021 May 26;9:99. doi: 10.1186/s40478-021-01185-8

Fig. 3.

Fig. 3

High sensitivity detection of tau seeding from biological sources. a Dose response curves of P301S v2H cells with protein from PS19 transgenic, wild-type, and tau knock-out mouse brain. b Dose response curves using protein from frontal lobe tissue of 5 AD cases. c, d Expansions of (a, b), respectively. LLD was 316 pg for PS19 brain, 305 pg for AD1, 153 pg for AD2, 1.2 ng for AD3, 78 ng for AD4, and 1.2 ng for AD5. Error bars are the SEM of 3 technical replicates over which each sample was divided