Table 2.
Biomarker collection
| Biomarkers | |
|---|---|
| Imaging | |
| Molecular | |
| Amyloid PET | Standardized uptake value ratio |
| Tau PET | Standardized uptake value ratio |
| Fluorodeoxyglucose PET | Standardized uptake value ratio |
| Magnetic resonance | |
| T1 3D MP-RAGE | Gray matter volume |
| 3D FLAIR | White matter lesions volume |
| rsfMRI | Functional connectivity at rest |
| DTI | Mean diffusivity, radial diffusivity, fractional anisotropy, axonal density, intra-axonal injury, inflammation |
| SWI | Number of Microbleeds |
| ASL | Gray matter perfusion indexes |
| FLUID | |
| CSF | Aβ40, Aβ42, P-tau, T-tau |
| Blood | Aβ40, Aβ42, P-tau181, P-tau217, NfL, APOE, inflammatory markers |
| Stool and saliva | Gut microbiota composition |