Table 5.
Histopathology score based on tubular degeneration/regeneration and urinary biomarkers of kidney injury following subcutaneous dosing of PMB, compounds 44 and 46 in the mouse
| PMB 12.5 mg/kg |
PMB 25 mg/kg |
44 25 mg/kg |
46 25 mg/kg |
|
|---|---|---|---|---|
| Kidney Histopathology Score: | ||||
| Zero | 1 | 0 | 6 | 6 |
| Minimal | 5 | 6 | 0 | 0 |
| Urinary Biomarkers: | ||||
| KIM-1 (ng/24h) | 1.6* | ≥58.2 | 0.9* | 2.3* |
| Cystatin C (ng/24h) | 591* | 1425 | 754* | 893* |
| Albumin (μg/24h) | 284* | 1147 | 343* | 749 |
*
For urinary biomarkers, indicates significantly different (p ≤ 0.05) to PMB at 25mg/kg