Skip to main content
. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Pharm Sci. 2020 Sep 12;109(12):3716–3727. doi: 10.1016/j.xphs.2020.09.011

Figure 3.

Figure 3.

Far-UV circular dichroism spectra of EBOV-GP (a) lyophilized formulations, (b) liquid in ammonium acetate formulations, and (c) liquid in phosphate buffered saline formulations that were freshly prepared (black solid line), incubated for 4 weeks (red solid line for 25°C and blue solid line for 40°C), or incubated for 12 weeks (red dashed line for 25°C and blue dashed line for 40°C). Non-incubated spectral shapes consisted of an overall peak minimum around 208 nm, indicated by an arrow shown in (a). Changes in overall peak minimum were monitored over the incubation period, shown in (d) where solid markers represent incubation at 25°C and open markers represent incubation at 40°C for lyophilized (circles), liquid in ammonium acetate with trehalose (triangles), and liquid in PBS (squares) formulations.