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. Author manuscript; available in PMC: 2021 Dec 1.
Published in final edited form as: J Pharm Sci. 2020 Sep 12;109(12):3716–3727. doi: 10.1016/j.xphs.2020.09.011

Table 1.

Summarized excipient conditions for MARV-GP vaccine formulations. For PS-20, the critical micelle concentration (CMC) is 0.06 mg/mL.

Group # Trehalose conc. Surfactant level (PS-20) Salt level (ammonium acetate) pH
MARV-GP LYO Salt #1 9.5% (w/v) --- 25 mM 7
MARV-GP LYO Salt #2 9.5% (w/v) --- 50 mM 7
MARV-GP LYO Salt #3 9.5% (w/v) --- 100 mM 7
MARV-GP LYO Surf #1 9.5% (w/v) ½× CMC = 0.03 mg/mL 10 mM 7
MARV-GP LYO Surf #2 9.5% (w/v) 2× CMC = 0.12 mg/mL 10 mM 7
MARV-GP LYO Surf #3 9.5% (w/v) 4× CMC = 0.24 mg/mL 10 mM 7
MARV-GP LYO pH #1 9.5% (w/v) --- 10 mM 5.5
MARV-GP LYO pH #2 9.5% (w/v) --- 10 mM 6.5
MARV-GP LYO pH #3 9.5% (w/v) --- 10 mM 7.5