Supplementary Table 2.
. Multivariable logistic regression analyses of the associations between HIV status and mortality in a COVID hospitalized cohort of patients.
| Variables | Mortality in hospitalized COVID patient cohort | |||||
|---|---|---|---|---|---|---|
| Model 1: Demographics, clinical and complications aOR (95% CI) | P-Value | Model 2: Demographics, clinical and laboratory markers aOR (95% CI) | P-value | Model 3: Demographics, clinical, complications and laboratory markers aOR (95% CI) | P-value | |
| HIV status | ||||||
| Negative | Ref | Ref | Ref | |||
| Positive | 1.14 (0.50–2.60) | 0.750 | 0.50 (0.20–1.40) | 0.179 | 0.45 (0.12-1.66) | 0.231 |
| Race | ||||||
| Black | Ref | Ref | Ref | |||
| White | 1.10 (0.32–3.60) | 0.916 | 1.8 (0.4–7.5) | 0.406 | 0.60 (0.08-4.5) | 0.609 |
| Other* | 0.60 (0.15–2.20) | 0.416 | 0.6 (0.2–2.6) | 0.541 | 0.73 (0.12-4.3) | 0.729 |
| Gender | ||||||
| Male | Ref | Ref | Ref | |||
| Female | 0.70 (0.32–1.40) | 0.319 | 0.80 (0.34–1.83) | 0.576 | 0.60 (0.21-1.72) | 0.340 |
| Age | 1.04 (1.01–1.07) | 0.024 | 1.02 (0.99–1.06) | 0.125 | 1.04 (0.99-1.08) | 0.076 |
| Respiratory support | ||||||
| No | Ref | Ref | Ref | |||
| Yes | 3.3 (1.2–9.0) | 0.019 | 3.04 (0.88–10.5) | 0.078 | 5.6 (1.0-31.3) | 0.05 |
| ICU required | ||||||
| No | Ref | Ref | Ref | |||
| Yes | 4.1 (2.0–9.4) | 0.001 | 9.4 (3.9–22.9) | <0.001 | 6.0 (2.0-18.8) | 0.002 |
| Chronic-Liver cirrhosis | - | |||||
| No | Ref | Ref | ||||
| Yes | 13.6 (2–109) | 0.014 | - | 2.7 (0.14-50) | 0.501 | |
| Complication_neuropsychiatric | - | |||||
| No | Ref | Ref | ||||
| Yes | 7.1 (1.2–42) | 0.031 | - | 73 (2.6-1998) | 0.011 | |
| Complication_cardiovascular | - | |||||
| No | Ref | Ref | ||||
| Yes | 15.6 (6.0–42) | <.001 | - | 19 (5.2-67) | <0.001 | |
| Chronic-Cardiovascular | - | |||||
| No | Ref | Ref | ||||
| Yes | 0.3 (0.13–0.60) | 0.003 | - | 0.4 (0.13-1.3) | 0.124 | |
| Chronic-Kidney Disease | - | |||||
| No | Ref | Ref | ||||
| Yes | 6.1 (2.0–21) | 0.004 | - | 5.0 (0.8-29.5) | 0.075 | |
| Chronic -Cancer | - | - | ||||
| No | Ref | |||||
| Yes | 1.9 (0.5–8.1) | 0.370 | - | - | ||
| Complication_infection | - | |||||
| No | Ref | Ref | ||||
| Yes | 20 (3.3–121) | 0.001 | - | 37 (4.4-309) | 0.001 | |
| Complication_AKI | ||||||
| No | Ref | Ref | ||||
| Yes | 2.3 (1.0–5.4) | 0.05 | 1.7 (0.5-5.5) | 0.349 | ||
| Chronic-Diabetes mellitus | - | - | ||||
| No | Ref | |||||
| Yes | 1.4 (0.6–3.2) | 0.434 | - | - | ||
| Chronic-Obesity | - | - | ||||
| No | Ref | |||||
| Yes | 1.3 (0.5–3.2) | 0.628 | - | - | ||
| Haemoglobin g/dl | - | 1.04 (0.89–1.22) | 0.631 | - | ||
| Platelets x109/l | - | 0.99 (0.98–0.998) | 0.007 | 0.99 (0.98-0.998) | 0.011 | |
| Urea mmol/l | - | 1.05 (1.01–1.10) | 0.011 | 1.04 (0.99-1.10) | 0.140 | |
| D-dimers mg/l | - | 1.01 (0.97–1.05) | 0.494 | 1.02 (0.98-1.07) | 0.283 | |
| Total Protein g/l | - | 1.08 (1.03–1.14) | 0.004 | 1.08 (1.01-1.16) | 0.017 | |
| Albumin g/l | - | 0.88 (0.80–0.95) | 0.002 | 0.89 (0.81-0.98) | 0.015 | |
| Total bilirubin umol/l | - | 0.93 (0.86–1.01) | 0.105 | 0.89 (0.80-0.98) | 0.016 | |
| Conjugate bilirubin umol/l | - | 1.15 (1.01–1.31) | 0.037 | 1.19 (1.02-1.40) | 0.020 | |
| Gamma-glutamyl transferase U/l | - | 1.0 (0.99–1.003) | 0.767 | - | - | |
Notes: Model 1 adjusts for demographics, clinical and comorbidities/complications, Model 2 adjusts for demographics, clinical and laboratory variables while Model 3 adjusts for demographics, clinical, selected comorbidities/complications and laboratory variables. Gender, age, race, HIV status, respiratory support and whether ICU was required were included in all models.