Table 7.

Mechanistic analysis of release kinetics of spherules retained in sieve numbers 22 and 44.

Kinetic models	Uncoated spherules (f1)			Single coated spherules (EC and Eudragit L-100 in 1:1 ratio) (f2)		Double coated EC and Eudragit L-100 spherules (f3)		Double coated EC spherules (f4)
Sieve no.	22		44	22	44	22	44	22	44
Zero-order	R2	0.70	0.48	0.66	0.66	0.62	0.80	0.66	0.69
	n	32.2	25.30	11.27	9.92	11.02	11.73	7.81	9.03
First-order	R2	0.84	0.66	0.88	0.82	0.95	0.95	0.86	0.99
	n	0.32	0.28	0.13	0.08	0.08	0.10	0.03	0.04
Higuchi model	R2	0.88	0.72	0.89	0.88	0.87	0.96	0.90	0.91
	n	56.68	48.71	33.68	29.45	33.47	32.96	23.4	26.6
Korsmeyer- Peppas model	R2	0.60	0.88	0.96	0.83	0.95	0.91	0.94	0.96
	n	0.20	0.10	0.18	0.18	0.17	0.30	0.23	0.21