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. 2021 May 13;11(5):311. doi: 10.3390/metabo11050311

Figure 2.

Figure 2

Comparison of COX-mediated metabolites in astrocytes, cultivated in normal (5.5 mM) and high (25 mM) glucose medium. Primary rat astrocytes were cultivated in normal (5.5 mM) or high (25 mM) glucose medium and then stimulated with lipopolysaccharide (LPS, 100 ng/mL) for 4 h. Concentrations of oxylipins in supernatants were measured using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). Pie plots showing the distribution of COX-mediated metabolites, released from (A) naive or (B) LPS-stimulated astrocytes. Abbreviations: TXB2-thromboxane B2, HETE-hydroxyeicosatetraenoic acids, HDoHE-hydroxydocosahexaenoic acids, HHT-hydroxyheptadecatrenoic acid, 6-keto-PGF1a-6-keto-prostaglandin F1a, PGA2-prostaglandin A2, PGJ2-prostaglandin J2, PGE2-prostaglandin E2, PGD2-prostaglandin D2, PGF2a-Prostaglandin F2a.