Fig. 4.

mGluR-LTD in WT and Ts1Cje hippocampal slices. A Time course of DHPG effects on field excitatory postsynaptic potentials (fEPSP) in WT and Ts1Cje mice. Upper insets: representative traces of a fEPSP before (1, 2) and after (1ʹ, 2ʹ) DHPG application in WT (1, 1ʹ) and Ts1Cje (2, 2ʹ) mice. The mean fEPSP slopes before DHPG perfusion between WT and Ts1Cje mice were not different. B Quantification of the effects depicted in A. The error bars represent the SEM. The number of slices for each condition is indicated in the corresponding bar (WT: 8 slices from 4 mice; Ts1Cje: 7 slices from 3 mice). p = 0.039 Student’s t-test