Table 1.
Proteins involved in mitochondrial pathways affected in Ts1Cje SNs
| Symbol | Entrez gene name | ID | Ts1Cje | Pathway |
|---|---|---|---|---|
| APP | Amyloid beta precursor protein | P12023 | 1.246 |
Mitochondrial dysfunction Sirtuin signaling |
| ATP5MF | ATP synthase membrane subunit f | P56135 | 1.925 |
Mitochondrial dysfunction Oxidative phosphorylation |
| ATP5PD | ATP synthase peripheral stalk subunit d | Q9DCX2 | 1.523 |
Mitochondrial dysfunction Oxidative phosphorylation |
| ATP5PF | ATP synthase peripheral stalk subunit F6 | P97450 | 1.907 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| COX4I1 | Cytochrome c oxidase subunit 4I1 | P19783 | 1.818 |
Mitochondrial dysfunction Oxidative phosphorylation |
| COX5A | Cytochrome c oxidase subunit 5A | P12787 | 1.889 |
Mitochondrial dysfunction Oxidative phosphorylation |
| Cox6c | Cytochrome c oxidase subunit 6C | Q9CPQ1 | 2.119 |
Mitochondrial dysfunction Oxidative phosphorylation |
| CYC1 | Cytochrome c1 | Q9D0M3 | 1.728 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| CYCS | Cytochrome c. somatic | P62897 | 1.976 |
Mitochondrial dysfunction Oxidative phosphorylation |
| GPD2 | Glycerol-3-phosphate dehydrogenase 2 | Q64521 | 1.549 | Mitochondrial dysfunction |
| MAOB | Monoamine oxidase B | Q8BW75 | 1.235 | Mitochondrial dysfunction |
| MT-CO2 | Cytochrome c oxidase subunit II | P00405 | 2.804 |
Mitochondrial dysfunction Oxidative phosphorylation |
| NDUFA2 | NADH:ubiquinone oxidoreductase subunit A2 | Q9CQ75 | 1.337 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFA4 | NDUFA4 mitochondrial complex associated | Q62425 | 1.331 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFA8 | NADH:ubiquinone oxidoreductase subunit A8 | Q9DCJ5 | 1.546 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFAF1 | NADH:ubiquinone oxidoreductase complex assembly factor 1 | A2AQ17 | 1.359 |
Mitochondrial dysfunction Sirtuin signaling |
| NDUFS1 | NADH:ubiquinone oxidoreductase core subunit S1 | Q91VD9 | 1.813 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFS3 | NADH:ubiquinone oxidoreductase core subunit S3 | Q9DCT2 | 1.713 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFS6 | NADH:ubiquinone oxidoreductase subunit S6 | P52503 | 1.368 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| NDUFV2 | NADH:ubiquinone oxidoreductase core subunit V2 | Q9D6J6 | 1.487 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| SLC25A4 | Solute carrier family 25 member 4 | P48962 | 1.591 | Sirtuin signaling |
| UQCRB | Ubiquinol-cytochrome c reductase binding protein | Q9CQB4 | 1.928 |
Mitochondrial dysfunction Oxidative phosphorylation |
| UQCRC1 | Ubiquinol-cytochrome c reductase core protein 1 | Q9CZ13 | 1.687 |
Mitochondrial dysfunction Oxidative phosphorylation |
| UQCRFS1 | Ubiquinol-cytochrome c reductase. Rieske iron-sulfur polypeptide 1 | Q9CR68 | 3.192 |
Mitochondrial dysfunction Oxidative phosphorylation Sirtuin signaling |
| UQCRQ | Ubiquinol-cytochrome c reductase complex III subunit VII | Q9CQ69 | 2.522 |
Mitochondrial dysfunction Oxidative phosphorylation |
| VDAC1 | Voltage dependent anion channel 1 | Q60932 | 1.762 |
Mitochondrial dysfunction Sirtuin signaling |
| VDAC2 | Voltage dependent anion channel 2 | Q60930 | 2.043 |
Mitochondrial dysfunction Sirtuin signaling |
| WRN | Werner syndrome RecQ like helicase | O09053 | − 1.341 | Sirtuin signaling |
The relative amounts (fold change, compared to WT SNs) of these proteins in Ts1Cje SNs are shown