Table 2.
Proteins involved in synaptic plasticity pathways affected in Ts1Cje SNs
| Symbol | Entrez gene name | ID | Ts1Cje | Pathway |
|---|---|---|---|---|
| ADCY9 | Adenylate cyclase 9 | P51830 | 1.344 |
CREB signaling Endocannabinoid neuronal synapse |
| ATP2A2 | ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 | O55143 | 1.251 | Calcium signaling |
| ATP2B1 | ATPase plasma membrane Ca2+ transporting 1 | G5E829 | 1.329 | Calcium signaling |
| ATP2B2 | ATPase plasma membrane Ca2+ transporting 2 | F8WHB1 | 1.268 | Calcium signaling |
| CACNA1A | Calcium voltage-gated channel subunit alpha1 A | P97445 | 1.314 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD |
| CACNA1G | Calcium voltage-gated channel subunit alpha1 G | Q5SUF8 | 1.474 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD |
| CACNA2D1 | Calcium voltage-gated channel auxiliary subunit alpha2delta 1 | O08532 | 1.262 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Synaptic LTD |
| GNB2 | G protein subunit beta 2 | E9QKR0 | 1.207 | CREB signaling |
| GNG2 | G protein subunit gamma 2 | P63213 | − 1.212 |
CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling |
| GRIA2 | Glutamate ionotropic receptor AMPA type subunit 2 | P23819 | 1.481 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD |
| GRIA4 | Glutamate ionotropic receptor AMPA type subunit 4 | Q9Z2W8 | − 1.251 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD |
| GRIN1 | Glutamate ionotropic receptor NMDA type subunit 1 | A2AI21 | 1.758 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling |
| GRIN2B | Glutamate ionotropic receptor NMDA type subunit 2B | Q01097 | 1.371 |
Calcium signaling CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling |
| GRM5 | Glutamate metabotropic receptor 5 | Q3UVX5 | 1.200 |
CREB signaling Endocannabinoid neuronal synapse Glutamate receptor signaling Synaptic LTD |
| RAP2B | RAP2B. member of RAS oncogene family | P61226 | 1.300 |
Calcium signaling CREB signaling Synaptic LTD |
| RYR2 | Ryanodine receptor 2 | E9Q401 | 1.251 |
Calcium signaling Synaptic LTD |
The relative amounts (fold change, compared to WT SNs) of these proteins in Ts1Cje SNs are shown