Table 1.
Summary of detected modules and related biological integration
| Module | # genes | # pheno. asso. | # enrichment | % muscle enrich. |
|---|---|---|---|---|
| 0 | 11 | NA | NA | NA |
| 1 | 5335 | 1 | 3288 | 0.6 |
| 2 | 3661 | 2 | 1098 | 0.4 |
| 3 | 3355 | 0 | 1620 | 0.3 |
| 4 | 1001 | 1 | 1883 | 1.0 |
| 5 | 987 | 0 | 1626 | 0.0 |
| 6 | 699 | 0 | 457 | 0.6 |
| 7 | 546 | 0 | 428 | 1.1 |
| 8 | 409 | 0 | 561 | 0.7 |
| 9 | 310 | 1 | 729 | 0.3 |
| 10 | 308 | 0 | 58 | 5.2 |
| 11 | 261 | 0 | 857 | 0.0 |
| 12 | 214 | 0 | 847 | 15.0 |
| 13 | 207 | 0 | 452 | 1.4 |
| 14 | 197 | 1 | 767 | 0.5 |
| 15 | 175 | 2 | 233 | 0.0 |
| 16 | 137 | 1 | 6 | 0.0 |
| 17 | 136 | 0 | 1 | 0.0 |
| 18 | 129 | 2 | 20 | 0.0 |
| 19 | 108 | 2 | 18 | 3.7 |
| 20 | 77 | 2 | 52 | 0.0 |
| 21 | 72 | 1 | 233 | 2.8 |
| 22 | 63 | 0 | 24 | 0.0 |
| 23 | 57 | 0 | 10 | 0.0 |
| 24 | 55 | 0 | 8 | 0.0 |
| 25 | 47 | 2 | 82 | 8.5 |
| 26 | 47 | 0 | 32 | 0.0 |
| 27 | 46 | 0 | 12 | 0.0 |
| 28 | 43 | 0 | 147 | 4.7 |
| 29 | 40 | 0 | 17 | 0.0 |
| 30 | 35 | 1 | 2 | 0.0 |
| 31 | 31 | 1 | 12 | 0.0 |
| 32 | 27 | 0 | 1 | 0.0 |
| 33 | 24 | 0 | 23 | 0.0 |
| 34 | 20 | 1 | 3 | 0.0 |
The number (#) of genes is indicated for each module (module 0 being a false module containing the unassigned genes. The number of phenotypic associations with the variables of interest (weight, sex, ethnicity, bmi, age) are counted for each one. The number of enrichments corresponds to the count of significant terms on each cumulative biological database. The ratio (%) of enriched terms associated with muscle is then established as the number of terms containing one or more elements of the following corpus: “muscle”, “sarco*”, “*”, “muscul*”, “actin*”, “myosin*” (where * denotes a completion by any other character string)