Table 6.

Results of external validation on CCLE and CTRP

Drug	Super. FELT	MOLIF	AE	ANNF	MOLI	Super.FELT E	Super.FELT M&C	Auto BorutaRF	SVM
17-AAG(CCLE)	0.682	0.666	0.628	0.656	0.678	0.669	0.481	0.530	0.717
Afatinib(CTRP)	0.798	0.783	0.771	0.788	0.776	0.794	0.605	0.541	0.793
Axitinib(CTRP)	0.795	0.777	0.795	0.761	0.752	0.796	0.631	0.521	0.794
AZD7762(CTRP)	0.797	0.785	0.777	0.762	0.794	0.800	0.681	0.526	0.746
AZD8055(CTRP)	0.679	0.693	0.698	0.659	0.688	0.680	0.622	0.508	0.693
BI-2536(CTRP)	0.510	0.526	0.473	0.510	0.547	0.507	0.487	0.632	0.678
Bleomycin(CTRP)	0.631	0.602	0.569	0.614	0.605	0.632	0.594	0.500	0.574
BMS-345541(CTRP)	0.740	0.756	0.759	0.716	0.721	0.757	0.606	0.756	0.756
BMS-754807(CTRP)	0.671	0.665	0.691	0.649	0.662	0.677	0.510	0.666	0.690
Bortezomib(CTRP)	0.283	0.274	0.258	0.287	0.333	0.250	0.465	0.489	0.751
Bosutinib(CTRP)	0.794	0.778	0.773	0.760	0.730	0.791	0.624	0.688	0.727
CAL-101(CTRP)	0.772	0.748	0.748	0.724	0.734	0.764	0.642	0.751	0.748
Crizotinib(CCLE)	0.718	0.717	0.625	0.715	0.735	0.706	0.586	0.673	0.773
Cytarabine(CTRP)	0.831	0.810	0.830	0.781	0.809	0.834	0.713	0.739	0.845
Dabrafenib(CTRP)	0.840	0.824	0.832	0.810	0.821	0.838	0.755	0.886	0.785
Dasatinib(CTRP)	0.669	0.664	0.633	0.669	0.647	0.660	0.519	0.660	0.639
Docetaxel(CTRP)	0.469	0.412	0.354	0.450	0.476	0.458	0.497	0.412	0.538
Doxorubicin(CTRP)	0.669	0.634	0.606	0.555	0.654	0.655	0.631	0.532	0.563
Erlotinib(CCLE)	0.698	0.665	0.704	0.667	0.680	0.702	0.525	0.555	0.722
Etoposide(CTRP)	0.824	0.813	0.827	0.731	0.770	0.826	0.690	0.736	0.719
EX-527(CTRP)	0.739	0.706	0.721	0.700	0.774	0.724	0.570	0.764	0.747
GDC0941(CTRP)	0.704	0.702	0.727	0.693	0.723	0.699	0.618	0.651	0.648
Gefitinib(CTRP)	0.690	0.683	0.684	0.656	0.675	0.692	0.562	0.649	0.698
Gemcitabine(CTRP)	0.614	0.598	0.671	0.557	0.583	0.644	0.655	0.523	0.562
GW843682X(CTRP)	0.454	0.534	0.413	0.483	0.582	0.469	0.486	0.576	0.660
Imatinib(CTRP)	0.682	0.679	0.648	0.690	0.698	0.691	0.549	0.596	0.791
JNJ-26854165(CTRP)	0.740	0.707	0.698	0.650	0.745	0.739	0.701	0.671	0.667
KU-55933(CTRP)	0.653	0.661	0.646	0.650	0.647	0.665	0.544	0.665	0.639
Lapatinib(CTRP)	0.661	0.638	0.692	0.662	0.610	0.656	0.548	0.588	0.688
Masitinib(CTRP)	0.820	0.813	0.816	0.821	0.809	0.822	0.721	0.807	0.815
Methotrexate(CTRP)	0.729	0.722	0.724	0.730	0.699	0.746	0.535	0.684	0.762
MG-132(CTRP)	0.374	0.433	0.355	0.403	0.372	0.363	0.626	0.492	0.641
Mitomycin C(CTRP)	0.707	0.655	0.627	0.593	0.662	0.699	0.584	0.526	0.627
MK-2206(CTRP)	0.733	0.733	0.710	0.717	0.742	0.733	0.642	0.754	0.753
Nilotinib(CCLE)	0.616	0.577	0.638	0.583	0.601	0.613	0.535	0.675	0.683
Nutlin-3a(CCLE)	0.928	0.906	0.868	0.910	0.938	0.908	0.906	0.928	0.902
NVP-BEZ235(CTRP)	0.636	0.584	0.543	0.607	0.583	0.626	0.576	0.512	0.616
NVP-TAE684(CTRP)	0.535	0.571	0.494	0.538	0.540	0.525	0.474	0.505	0.666
Obatoclax Mesylate(CTRP)	0.672	0.613	0.618	0.607	0.671	0.666	0.619	0.611	0.644
OSI-027(CTRP)	0.701	0.690	0.698	0.674	0.688	0.702	0.610	0.684	0.646
OSI-930(CTRP)	0.808	0.795	0.806	0.819	0.773	0.824	0.740	0.747	0.829
PAC-1(CTRP)	0.734	0.660	0.706	0.661	0.729	0.713	0.706	0.812	0.760
Paclitaxel(CTRP)	0.449	0.405	0.352	0.436	0.414	0.343	0.453	0.547	0.722
Parthenolide(CTRP)	0.623	0.642	0.546	0.616	0.592	0.580	0.601	0.609	0.708
Pazopanib(CTRP)	0.680	0.635	0.616	0.659	0.631	0.661	0.602	0.651	0.679
PD-0325901(CCLE)	0.854	0.841	0.843	0.821	0.840	0.852	0.635	0.828	0.826
PD-0332991(CCLE)	0.645	0.609	0.678	0.552	0.651	0.645	0.680	0.676	0.629
PHA-665752(CCLE)	0.524	0.553	0.487	0.535	0.527	0.534	0.504	0.495	0.612
PHA-793887(CTRP)	0.822	0.808	0.835	0.818	0.815	0.813	0.720	0.798	0.826
PI-103(CTRP)	0.785	0.759	0.758	0.742	0.734	0.751	0.643	0.750	0.781
PIK-93(CTRP)	0.817	0.821	0.826	0.807	0.828	0.820	0.718	0.844	0.814
piperlongumine(CTRP)	0.727	0.639	0.682	0.627	0.657	0.740	0.658	0.616	0.585
PLX4720(CCLE)	0.875	0.873	0.871	0.839	0.868	0.884	0.640	0.781	0.870
Ruxolitinib(CTRP)	0.763	0.756	0.775	0.745	0.744	0.773	0.619	0.769	0.777
SN-38(CTRP)	0.735	0.730	0.717	0.675	0.749	0.721	0.620	0.742	0.776
SNX-2112(CTRP)	0.800	0.789	0.782	0.740	0.793	0.779	0.633	0.759	0.672
Sorafenib(CCLE)	0.552	0.633	0.555	0.666	0.623	0.627	0.576	0.595	0.773
Sunitinib(CTRP)	0.552	0.642	0.578	0.628	0.591	0.570	0.589	0.580	0.755
Tamoxifen(CTRP)	0.617	0.630	0.591	0.619	0.575	0.632	0.516	0.609	0.701
Temozolomide(CTRP)	0.834	0.827	0.820	0.826	0.818	0.825	0.609	0.771	0.794
Temsirolimus(CTRP)	0.731	0.692	0.689	0.654	0.679	0.726	0.688	0.762	0.748
TG101348(CTRP)	0.771	0.786	0.803	0.754	0.774	0.770	0.696	0.790	0.781
TGX221(CTRP)	0.461	0.421	0.414	0.544	0.455	0.476	0.434	0.646	0.646
TPCA-1(CTRP)	0.784	0.779	0.788	0.778	0.795	0.777	0.668	0.793	0.795
Trametinib(CTRP)	0.772	0.783	0.746	0.772	0.770	0.761	0.597	0.717	0.773
Tubastatin A(CTRP)	0.870	0.866	0.888	0.865	0.865	0.872	0.739	0.895	0.878
TW 37(CTRP)	0.599	0.444	0.504	0.512	0.520	0.606	0.511	0.505	0.527
Vorinostat(CTRP)	0.793	0.820	0.847	0.776	0.749	0.799	0.619	0.826	0.745
VX-680(CTRP)	0.724	0.773	0.719	0.715	0.802	0.749	0.679	0.750	0.899
YK 4-279(CTRP)	0.786	0.763	0.785	0.759	0.765	0.800	0.574	0.628	0.747
YM155(CTRP)	0.662	0.591	0.602	0.601	0.513	0.507	0.481	0.505	0.632
ZSTK474(CTRP)	0.773	0.783	0.779	0.756	0.729	0.771	0.651	0.753	0.770
AVG	0.697	0.685	0.677	0.674	0.685	0.693	0.607	0.663	0.721

Bold values indicate methods with best performance for each drug