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. 2021 May 26;12:299. doi: 10.1186/s13287-021-02363-0

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — MMVs delivered mfn2 to IEC-6 to improve the proliferation and barrier function. a Effect of modified MMVs on TEER of IEC-6 (n=5). b Effect of modified MMVs on BSA leakage of IEC-6 (n=6). c Effect of modified MMVs on CCK8 proliferation assay of IEC-6 (n=6). d The relative expression of PCNA in IEC-6 treated by modified MMVs. β-actin was used as the internal reference (n=5). e Representative microphotographs of scratch migration assay and the scratched area of IEC-6 treated by modified MMVs. The scale bar represents 100μm. f Representative IF microphotographs of ZO-1 in IEC-6 treated by modified MMVs. The scale bar represents 20μm. Ctl, normal control group; LPS, LPS-stimulated group; CMV, CMV-treated group; MMV, MMV-treated group; MMV^mfn2-up, mfn2 upregulation in MMVs; MMV^mfn2-down, mfn2 downregulation in MMVs; MMV^vehicle, mfn2-mocktransfection in MMVs. **P < 0.01, *P < 0.05