Table 3.
Associations of premenstrual disorders (PMD) with subsequent risk of injury, stratified by psychiatric comorbidities
| Population analysis | Sibling analysis a | |||||||
|---|---|---|---|---|---|---|---|---|
| Reference N (IR) | PMD N (IR) | HR (95% CI) b | P for interaction | Reference N (IR) | PMD N (IR) | HR (95% CI) b | P for interaction | |
| Any injury | ||||||||
| By psychiatric comorbidities | ||||||||
| No | 306,980 (22.2) | 1923 (23.1) | 1.34 (1.28–1.40) | 0.010 | 130,121 (21.5) | 795 (23.2) | 1.25 (1.08–1.41) | 0.304 |
| Yes | 29,652 (46.6) | 467 (46.7) | 1.17 (1.06–1.28) | 11,556 (44.1) | 178 (45.3) | 1.54 (1.01–2.07) | ||
| Suicidal behavior | ||||||||
| By psychiatric comorbidities | ||||||||
| No | 12,678 (0.8) | 70 (0.8) | 1.76 (1.34–2.19) | 0.437 | 5156 (0.7) | 28 (0.7) | 1.41 (0.48–2.34) | 0.870 |
| Yes | 9742 (11.8) | 146 (12.3) | 1.60 (1.33–1.86) | 3755 (11.1) | 61 (13.3) | 1.50 (0.29–2.70) | ||
| Accidents | ||||||||
| By psychiatric comorbidities | ||||||||
| No | 288,068 (20.7) | 1821 (21.7) | 1.32 (1.26–1.38) | 0.007 | 122,255 (20.1) | 754 (22.0) | 1.26 (1.09–1.43) | 0.783 |
| Yes | 24,903 (34.8) | 370 (34.5) | 1.12 (1.00–1.24) | 9750 (33.2) | 141 (33.4) | 1.37 (0.89–1.84) | ||
N number, IR crude incidence rate per 1000 person-years, HR hazard ratio, CI confidence interval
aAnalyses were stratified on full sister sets
bHRs were controlled for attained age as the underlying timescale and additionally adjusted for calendar year of birth (1960–1965, 1966–1970, 1971–1975, 1976–1980, 1981–1985, or 1986–1990), educational level (primary school, high school, college and beyond, or unknown), region of residence (south, middle, or north of Sweden), and history of injury (yes or no)