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. 2021 Apr 24;10(5):1002. doi: 10.3390/cells10051002

Figure 1.

Figure 1

KLF5 copy number variations (CNV) in 33 cancer types. (A) Barplot showing the proportions of KLF5 CNV across 33 tumor types. The full name of each tumor type is given in the Public datasets section from the Materials and Methods. The dots below the bars indicate different types of CNV status of KLF5. The red dot indicates KLF5 is mainly amplified, the blue dot indicates KLF5 is mainly deleted, whereas the green dot indicates similar amplification and deletion rates of KLF5 in that tumor type. (B) Heatmap showing chromosome 13q copy number changes in three cancer types. In gastric cancer (STAD) and a subset of bladder cancer (BLCA), whole chromosome arm 13q duplication, as well as regional amplification, accounted for gaining of copy number in KLF5. In prostate cancer (PRAD) or other parts of bladder cancer, long segment deletion of chromosome 13q accounted for the loss of copy number in KLF5. (C) The room-in view of chromosome 13q that carries KLF5 amplification in gastric cancer. In the heatmap, red stands for amplification, blue stands for deletion, and white stands for the diploid gene.