Table 3.

Summary of cases and pregnancy outcomes with the use of eculizumab, anticoagulation therapy and documented complications (ante, intra, postpartum period)

Case number	Maternal age at PNH diagnosis (years)	Diagnostic test PNH clone size (%)		Clinical presentation	Maternal age at pregnancy (years)	Eculizumab		Anticoagulants in pregnancy (mg)	Transfusion	Complications			Follow up
		Granulocyte clone (%)	Monocyte, clone (%)			Before pregnancy (mg)	In pregnancy (mg)			Antepartum	Intrapartum	Postpartum
1	36	67	63	Fatigue, dizziness, heavy mensuration AA thrombocytopenia	39	900	1200	LMWH	RBC, PLT	Polyhydramnios, fetus LGA	Thrombocytopenia	PVT, PLT Trans	Stable
2.1	25	56.7	48.2	Fatigue	22	None	None	LMWH	RBC	None	None	None	Stable
2.2				AA	23	None	None	LMWH	RBC	Epistaxis, dark urine	None	None	Stable
2.3					29	None	None	LMWH	None	Abdominal pain, PV bleeding	Missed Ab	None
3.1	32	76.8	80.6	Fatigue, abdominal pain, dizziness, skin thrombophlebitis	37	Refused	600	Fondaparinux, HIT positive	RBC, PLT	PROM, PV, BMS exacerbation	None	None	Stable
3.2					38	600	600	Unknown	Unknown	Unknown	Missed Ab	Unknown
3.3				AA	38	600	600	Not yet started (1st trimester)	None	None	Pregnant	Pregnant	-
4.1	32	43.2	78.3	Back pain	35	900	600	LMWH	RBC, PLT	IUFD	None	None	Stable
4.2				AA	36	900	900	LMWH	None	IUFD followed by SCA	None	None	Stable
4.3				Pancytopenia HepB	37	900	900	None	None	None	Sp Ab	None	-

PNH – Paroxysmal nocturnal hemoglobinuria; AA – Aplastic anemia; PROM – Preterm rupture of membranes; LGA – Large for gestational age; PVT – Portal vein thrombosis; PV – Per vaginal; BMS – Bone marrow suppression; HepB – Hepatitis B; IUFD – Intrauterine fetal death; SCA – Spontaneous complete abortion. LMWH – Low-molecular-weight heparin; RBC – Red blood cells; PLT – Platelets; SP – Spontaneous; AB – Abortion; HIT – Heparin indiced thrombocytopenia