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| Reaction class | Reaction name | Fraction of USPTO_50k (%) | Fraction of USPTO_MIT (%) |
|---|---|---|---|
| 1 | Heteroatom alkylation and arylation | 30.3 | 29.9 |
| 2 | Acylation and related processes | 23.8 | 24.9 |
| 3 | C–C bond formation | 11.3 | 13.4 |
| 4 | Heterocycle formation | 1.8 | 0.7 |
| 5 | Protections | 1.3 | 0.3 |
| 6 | Deprotections | 16.5 | 14.1 |
| 7 | Reductions | 9.2 | 9.4 |
| 8 | Oxidations | 1.6 | 2.0 |
| 9 | Functional group interconversion (FGI) | 3.7 | 5.0 |
| 10 | Functional group addition (FGA) | 0.5 | 0.2 |
