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. 2021 Jan 22;42(3):354–373. doi: 10.1210/endrev/bnab002

Figure 1.

Figure 1.

Pathways and enzymes to production of DHT. Steroid metabolism pathways and key enzymes for production of DHEA in the adrenal glands and conversion of DHEA to the potent androgen DHT in the prostate. Note that there are numerous isoforms of 17β-hydroxysteroid dehydrogenase; types 3 and 5 in particular are thought to be the important enzymes with reductive preference in prostate cancer (62).