Overview of potential therapeutic approaches for targeting autoreactive B cells. Stimulatory and inhibitory checkpoints of B cells such as CD40, Toll-like receptors (TLRs), B cell-activating factor receptor (BAFFR), programmed cell death 1 (PD1), low-affinity immunoglobulin-γ Fc region receptor IIb (FcγRIIb), and CD22; Bruton’s tyrosine kinase (BTK); glycosylation patterns of the variable (Fab) region of the B cell receptor (BCR); targets based on the unique gene expression profiles of autoreactive B cells compared to autologous non-autoreactive B cells; and the autoantigen-specific BCR of autoreactive B cells. Figure was created with BioRender.