. Author manuscript; available in PMC: 2021 May 26.

Published in final edited form as: Inorganics (Basel). 2020 Jan 26;8(2):10. doi: 10.3390/inorganics8020010

Table 1.

Antiproliferative activities of Au(I) complexes against cancer cell lines and inhibition at 5 μM of TrxR activity [104].

Compounds	Cancer Cells IC₅₀ (μM ± SD)			Non-Cancer Cell BHK21	TrxR Inhibition (% ± SD)
Compounds	B16-F10 Melanoma	CT26-WT Colon	4T1 Breast	Non-Cancer Cell BHK21	TrxR Inhibition (% ± SD)
AuPPh₃ATT	5.7 ± 0.5	5.7 ± 0.9	6.6 ± 0.5	18.5 ± 2.9	40.7 ± 1.5
AuPEt₃ATT	1.2 ± 0.2	1.8 ± 0.8	1.6 ± 0.5	5.5 ± 0.1	51.6 ± 1.6
AuPPh₃MOT	1.8 ± 0.5	1.8 ± 0.3	3.0 ± 1.8	6.9 ± 0.8	57.3 ± 0.7
AuPEt₃MOT	1.0 ± 0.1	0.9 ± 0.1	1.1 ± 0.2	5.8 ± 0.1	60.2 ± 0.7
AuPPh₃Cl	6.6 ± 0.1	12.1 ± 2.8	10.3 ± 2.3	23.0 ± 0.3	-
AuPEt₃Cl	2.3 ± 0.5	9.0 ± 0.7	9.5 ± 1.1	22.5 ± 0.2	-
AF	0.5 ± 0.4	0.5 ± 0.4	0.6 ± 0.2	1.6 ± 0.5	59.7 ± 1.5