Table 1.
Median IC50 values for pracinostat in the different lymphoma histologies screened
| Histology | Median, nM | 95% CI | n |
|---|---|---|---|
| ABC-DLBCL | 173.8 | 104.1-434.6 | 8 |
| GCB-DLBCL | 232.4 | 116.5-459.2 | 17 |
| BCR-DLBCL | 170.7 | 76.3-523.9 | 8 |
| OxPhos-DLBCL | 865 | 514.4-1012.8 | 4 |
| MCL | 249.7 | 67.9-753.7 | 10 |
| MZL | 304.3 | 52.7-369.9 | 5 |
| CLL | 1148.3 | 639.1-1657.4 | 2 |
| PMBCL | 197.9 | N/A | 1 |
| CTCL | 317.6 | 134.6-370.3 | 3 |
| ALCL | 479.5 | 224-803.7 | 5 |
| PTCL-NOS | 339.9 | N/A | 1 |
| ATCL | 158.2 | N/A | 1 |
| HL | 298 | 158-509.5 | 4 |
| Canine DLBCL | 130.2 | N/A | 1 |
| Murine DLBCL | 231.9 | 166.6-297.1 | 2 |
For DLBCL, median IC50 values are shown for cell of origin (COO; ABC-DLBCL and GCB-DLBCL) and consensus clustering classification (CCC) subtypes (OxPhos-DLBCL and BCR-DLBCL).
ALCL, anaplastic large T-cell lymphoma; ATCL, angioimmunoblastic T-cell lymphoma; CI, confidence interval; CLL, chronic lymphocytic leukemia; MZL, marginal zone lymphoma; N/A, not available; PMBCL, primary mediastinal B-cell lymphoma; PTCL-NOS, peripheral T-cell lymphoma, not otherwise specified.